Immunohistochemical Expression of Sentinel
lymph nodes in Early breast cancer

Kang, Nam Uk; Cho, Se Heon; Lee, Mi Ri; Kim, Dae Cheol; Kim, Su Jin; Lee, Jin Hwa; Lee, Keon Cheol; Kwan, Hyuk Chan; Lee, Hyung Sik

doi:2010.6.1.70

Korean Journal of Clinical Oncology > Article

Original Article

Korean Journal of Clinical Oncology 2010;6(1): 70-78.

조기 유방암 환자에서 감시 림프절 내 면역조직화학적 발현양상

강남욱¹, 조세헌¹, 이미리¹, 김대철², 김수진², 이진화³, 이근철⁴, 권혁찬⁵, 이형식⁶

¹동아대학교 의과대학 외과학교실
²동아대학교 의과대학 병리학교실
³동아대학교 의과대학 영상의학과교실
⁴동아대학교 의과대학 성형외과학교실
⁵동아대학교 의과대학 내과학교실
⁶동아대학교 의과대학 치료방사선과학교실

Immunohistochemical Expression of Sentinel lymph nodes in Early breast cancer

Nam Uk Kang¹, Se Heon Cho¹, Mi Ri Lee¹, Dae Cheol Kim², Su Jin Kim², Jin Hwa Lee³, Keon Cheol Lee⁴, Hyuk Chan Kwan⁵, Hyung Sik Lee⁶

¹Department of Surgery, Dong-A University College of Medicine
²Department of Pathology, Dong-A University College of Medicine
³Department of Radiology, Dong-A University College of Medicine
⁴Department of Plastic surgery, Dong-A University College of Medicine
⁵Department of Internal medicine, Dong-A University College of Medicine
⁶Department of Therapeutic Radiology, Dong-A University College of Medicine

Corresponding Author: Dae Cheol Kim ,Tel: +82-51-240-2878, Fax: +82-51-980-0585, Email: freehand@dau.ac.kr

Received: May 20, 2010; Accepted: June 23, 2010.

ABSTRACT

Purpose : Sentinel lymph node (SLN) biopsy allows to identify the first lymph node into which a primary tumor drains. In breast cancer, identification of tumor cells in SLNs is one of the strong predictor of disease-free and overall survival for breast cancer patients. Its immunologic nature has been identified or established, and would provide us useful prognostic or predictable information on clinical outcome. Meterial and Methods : We performed immunohistochemical analysis of 149 SLN from 41 early breast cancers (T1/T2 and N0) between 2000 and 2003 at OOO University for 5 years. They had followed to determine immunoprofile alterations of CD4 helper, CD8 cytotoxic T cell and CD1a dendritic cell population whether they can predict distant metastasis or disease-free survival. Classical prognostic factors-tumor size, pathologic diagnosis, histological grade and nuclear grade were compared. Results : Immunohistocheminal expression of SLN appear independent of ER and PR, C-erbB2. Immunoprofile changes and clinical manifestation represent independent processes. Although more patients were alive at the 5- year time point in the group with higher CD4 helper, CD8 cytotoxic T cell and CD1a dendritic cell population, this failed to reach statistical significance at the p= 0.05 level. The larger the tumor size is, the more the expression of CD1a, CD8 in SLN is increased(p-value =0.01/0.03). Conclusion : The expression of CD1 and CD8 correlatated primary tumor size of breast cancer. These finding demomstrate that immune-activity of primary tumor influence tumor-draining lymph node. Analysis for long term follow-up post surgery is required to investigate the association further.

Keywords: Breast neoplasms | Sentinel lymph node | CD1a | CD4 | CD8