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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2011;7(2): 4-11.         doi: https://doi.org/10.14216/kjco.11013
Clinocopathologic Factors Affecting Actual 5-year Survival Rate of Invasive Ductal Carcinoma: a Single-center Analysis of 365 Patients
Chan-Ik Park1, JeeYeon Lee1, SangHwa Ko1, ChangIn Choi1, SangHyup Lee2, Hyung-il Seo1, YoungTae Bae1
1Department of Surgery, Breast Clinic, Pusan National University Hospital, College of Medicine, Busan, Republic of Korea
2Department of Surgery, Pusan National University Yangsan Hospital
침윤성 유관암에 있어 실제 5년 생존율에 관여하는 임상병리학적 인자: 365명을 대상으로 한 단일 기관 연구
박찬익1, 이지연1, 고상화1, 최창인1, 이상협2, 서형일1, 배영태1
1부산대학교 의학전문대학원 외과학교실, 유방클리닉
2양산부산대학교병원 외과학교실
Corresponding Author: YoungTae Bae ,Tel: +82-51-240-7238, Fax: +82-51-247-1365, Email: bytae@pusan.ac.kr
Received: September 23, 2011;  Accepted: October 20, 2011.
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Background The aim of this study is to figure out the clinicopathologic factors of invasive ductal carcinoma affecting to actual 5-year survival rate(5-YSR). Patients and Methods From Jan of 1999 to Dec of 2003, a total of 365 female patients with invasive ductal carcinoma who undergone operations in Pusan National University Hospital were enrolled for this study. The univariate and multivariate analysis were performed with clinicopathologic factors and actual 5-YSR. Results The mean age of patients was 47.6 years and mean follow-up period was 62.8 months. Thirty-nine of the 365 patients had expired within 5 years after operation and the actual 5-YSR was 89.3%. The variables affecting to actual 5-YSR of breast cancer in univariate analysis were preoperative CA 15-3 level(p=0.0211), tumor size(p<0.0000), axillary lymph nodes metastasis(p<0.0000), pathologic cancer stage(p<0.0000), lymphovascular(p=0.0004) and perineural invasion(p=0.0192) of primary tumor, positivity of progesterone receptor(p=0.0457) and HER2-neu gene(p=0.0179), breast-conserving surgery(p<0.0000), perioperative transfusion(p=0.0002), neoadjuvant and adjuvant chemotherapy(p<0.0000), treatment with tamoxifen(p=0.0380). But, in multivariate analysis, significant factors with actual 5-YSR were only pathologic tumor stage(p=0.0012) and adjuvant chemotherapy(p=0.0102). Conclusion The pathologic tumor stage and adjuvant chemotherapy were related with actual 5-YSR of invasive ductal carcinoma significantly. The adjuvant chemotherapy should be selected carefully with considering clinicopathologic factors of breast cancer, because various combinations are possible even if the pathologic tumor stage is difficult to change by physician.
Keywords: Clinicopathologic factors | Actual 5-year survival rate | Invasive ductal carcinoma
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