1Department of Surgery, Breast Clinic, Pusan National University Hospital, College of Medicine, Busan, Republic of Korea 2Department of Surgery, Pusan National University Yangsan Hospital
Received: September 23, 2011; Accepted: October 20, 2011.
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ABSTRACT
Background The aim of this study is to figure out the clinicopathologic factors of invasive ductal carcinoma
affecting to actual 5-year survival rate(5-YSR).
Patients and Methods From Jan of 1999 to Dec of 2003, a total of 365 female patients with invasive ductal
carcinoma who undergone operations in Pusan National University Hospital were enrolled for this study. The
univariate and multivariate analysis were performed with clinicopathologic factors and actual 5-YSR.
Results The mean age of patients was 47.6 years and mean follow-up period was 62.8 months. Thirty-nine of the
365 patients had expired within 5 years after operation and the actual 5-YSR was 89.3%. The variables affecting to
actual 5-YSR of breast cancer in univariate analysis were preoperative CA 15-3 level(p=0.0211), tumor
size(p<0.0000), axillary lymph nodes metastasis(p<0.0000), pathologic cancer stage(p<0.0000),
lymphovascular(p=0.0004) and perineural invasion(p=0.0192) of primary tumor, positivity of progesterone
receptor(p=0.0457) and HER2-neu gene(p=0.0179), breast-conserving surgery(p<0.0000), perioperative
transfusion(p=0.0002), neoadjuvant and adjuvant chemotherapy(p<0.0000), treatment with tamoxifen(p=0.0380).
But, in multivariate analysis, significant factors with actual 5-YSR were only pathologic tumor stage(p=0.0012) and
adjuvant chemotherapy(p=0.0102).
Conclusion The pathologic tumor stage and adjuvant chemotherapy were related with actual 5-YSR of invasive
ductal carcinoma significantly. The adjuvant chemotherapy should be selected carefully with considering
clinicopathologic factors of breast cancer, because various combinations are possible even if the pathologic tumor
stage is difficult to change by physician.
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