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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2011;7(1): 66-71.         doi: https://doi.org/10.14216/kjco.11011
Risk factors of locoregional recurrences in breast cancer
Inseok Park1, Kyeongmee Park2, Sehwan Han1, Ji-Young Kim3, Ki Whan Kim1, Byung Noe Bae1, Keun Ho Yang1, Geumhee Gwak1, Hyunjin Cho1, Sungjin Park4
1Department of Surgery, Inje University Sanggye Paik Hospital
2Department of Pathology, Inje University Sanggye Paik Hospital
3Department of Radiology, Inje University Sanggye Paik Hospital
4Department of Surgery, Inje University Haeundae Paik Hospital
유방암 환자에서 국소구역 재발과 관련된 인자
박인석1, 박경미2, 한세환1, 김지영3, 김기환1, 배병노1, 양근호1, 곽금희1, 조현진1, 박성진4
1인제대학교 상계백병원 외과학교실
2인제대학교 상계백병원 병리학교실
3인제대학교 상계백병원 영상의학교실
4인제대학교 해운대 백병원 외과학교실
Corresponding Author: Geumhee Gwak ,Tel: +82-2-950-1022, Fax: +82-2-933-9389, Email: gsrad@hanmail.net
Received: May 23, 2011;  Accepted: June 20, 2011.
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Purpose: Significant proportion of breast cancer patients with locoregional recurrence eventually die of their disease. This study was performed to investigate the risk factors associated with locoregional recurrence of breast cancer after breast conserving surgery.
Methods: We reviewed the medical records of 302 patients with breast cancer who underwent breast conserving surgery and analyzed the association between locoregional recurrences and clinico-pathological factors of each patients.
Results: The 26 of 302 patients (8.6%) developed locoregional recurrence during a median follow-up of 35.5 months. 18 patients (5.9%) had local recurrence, 6 patients (2.0%) had regional recurrence and 2 patients (0.7%) had locoregional recurrence. On univariate analysis, positive margin (p<0.0001), HER2/neu positive, extensive intraductal component, multiplicity were statistically significant risk factors for locoregional recurrence of breast cancer. On multivariate analysis, positive margin status, HER2/neu positivity and multiplicity were significantly associated with locoregional recurrence after breast conserving surgery.
Conclusion: Our study showed that adequate resection margin is the most important to reduce locoregional recurrence of breast cancer after breast conserving surgery. In addition, HER2/neu amplification or multiplicity increased the locoregional recurrence rate in breast cancer.
Keywords: Breast cancer | locoregional recurrence | margin status | risk factor
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