| Home | E-Submission | Sitemap | Contact Us |  
Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2012;8(2): 92-97.         doi: https://doi.org/10.14216/kjco.12023
Treatment of Squamous Cell Carcinoma of the Anal Margin: Single Center Experience
Ji Young Yoo, Dae Ro Lim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
Section of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
Corresponding Author: Nam Kyu Kim ,Tel: 02-2228-2105, Fax: 02-313-8289, Email: namkyuk@yuhs.ac
Received: October 18, 2012;  Accepted: December 10, 2012.
Share :  
Propose: Squamous cell carcinomas of the anal margin are rare disease among anorectal malignancies. The aim of this study is to define treatment of patients with squamous cell carcinoma of the anal margin. Material and Method: This is a retrospective study of 16 patients with squamous cell carcinoma of the anal margin diagnosed in ooo hospital between January 2008 and December 2011 who received different treatment options including surgery, as well as chemotherapy and/or radiotherapy. Total radiation dose ranged from 4,320 to 6,300cGy. The radiation fields were included to pelvis alone or pelvis plus both inguinal areas. The chemotherapy regimens were 5-FU in combination with either mitomycin-C or cisplatin.
Results: Fourteen patients were treated by radiation or chemoradiation therapy. Two patients were performed local excision. Thirteen patients achieved clinical complete response and one showed a partial response. Partial response of patient was treated with systemic chemotherapy after chemoradiation therapy. Previous diagnosis of 10 patients was hemorrhoid and 1 patient was condyloma acuminata. Two patients presented with palpable inguinal nodes, one with perianal mass, and another one with anal bleeding. Ten hemorrhoids and one condyloma acuminata were determined to be squamous cell carcinoma by postoperative permanent pathology. One case was categorized as stage 0 (TisN0 : 6.3%), 7 were stage I (43.7%), 4 were stage II (25.0%), and 4 were stage III(25.0%). After a median follow up of 62 months (range, 13-148 months), recurrence was found in 5 patients (31.3%). anus only (n = 2, 12.4%). The sites of recurrence were as follows: anus + vulva (n = 1, 6.3%), inguinal node only (n = 1, 6.3%) and lung + pelvic wall node (n = 1, 6.3%). The 5-year disease free and overall survival rates were 74.0% and 100%, respectively.
Conclusion: The radiation or chemoradiation therapy for treatment of squamous cell carcinoma of anal margin was effective for oncologic outcome and sphincter preservation.
Keywords: squamous cell carcinoma | anal margin | radiation or chemoradiation therapy
Editorial Office
101-3304 Brownstone Seoul, 464 Cheongpa-ro, Jung-gu, Seoul 04510, Korea
TEL : +82-2-393-2114   FAX : +82-2-393-1649   E-mail : office@kjco.org

Copyright© Korean Society of Surgical Oncology.                Developed in M2PI
About |  Browse Articles |  Current Issue |  For Authors and Reviewers