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Korean Journal of Clinical Oncology > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2012;8(2): 62-69.         doi: https://doi.org/10.14216/kjco.12019
Expression of epidermal growth factor receptor (EGFR) in phyllodes tumor
Ji Young Kim1, Ra Mi Kim1, Woo Sung Hong1, Hyun Ee Yim2, Tae Hee Kim3, Doo Kyoung Kang3, Yong Sik Jung1, Ku Sang Kim1,4
1Department of Surgery, Ajou University School of Medicine, Suwon, Korea
2Department of Pathology, Ajou University School of Medicine, Suwon, Korea
3Department of Radiology, Ajou University School of Medicine, Suwon, Korea
4Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea
Corresponding Author: Ku Sang Kim ,Tel: +82-31-219-5200, Fax: +82-31-219-5755, Email: ideakims@gmail.com
Received: August 31, 2012;  Accepted: January 6, 2013.
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ABSTRACT
Background: Phyllodes tumorof the breast is a rare stromal-epithelial neoplasm with the potential for invasion and metastatic spread, but the clinical behavior of phyllodes tumor is difficult to predict. Specific parameters that define recurrence and prognosis are not universally estabilished yet. We aim to reveal the relationship of EGFR espression and type of phyllodes tumor.
Methods: This study investigated 82 phyllodes tumors (57 benign, 11 borderline, 14 malignant) for EGFR expression using immunohistochemistry (IHC). The staining was correlated to tumor margin status, degree of malignancy, stromal cellularity, mitotic activity, nuclear pleomorphism and stromal overgrowth.
Results: There was an increasing trend of stromal EGFR staining with increasing degree of malignancy (p = 0.001 between benign and borderline tumors, p = 0.021 between borderline and malignant tumors, p < 0.001 between benign and malignant tumors).
Conclusion: We believe that our findings show that EGFR expression and histological parameters can be used for evaluation of breast phyllodes tumors.
Keywords: Phyllodes tumor | EGFR | Breast
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