| Non-Functional P2X7 Receptor; A New Biomarker for Colorectal Cancer |
| Young-ro Yang, Weon-young Chang |
| Department of Surgery, School of Medicine, Jeju National University |
| Corresponding Author:
Weon-young Chang ,Tel: +82-64-717-1522, Fax: +82-64-757-8276, Email: orkorea@jejunu.ac.kr |
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Received: August 24, 2012; Accepted: November 23, 2012. |
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| ABSTRACT |
P2X7 is an apoptotic APT receptor that is non-functional on cancer cells. It has been shown to be a reliable marker for identification of malignancy in the epithelial cells of cancers including the prostate, breast, skin and uterine cervix. In the prostate, the receptor locates strongly to the apical membrane of malignant cells and also similarly locates in adjacent“ normal”glands (a field effect). In this study, we tested the applicability of P2X7 as a biomarker in colorectal carcinogenesis.
Methods: We examined 330 endoscopic and surgical specimens from 158 consecutive patients. Cytoplasmic staining judged simply as positive or negative provided the best sensitivity and specificity.
Results: Staining in colonic neoplastic tissue was dominantly in the cytoplasm, although there was translocation to the nucleus in some patients. Sensitivity for cancer was 100% and for adenomas 82%. Specificity was 100% (negative in normal biopsies). There was no correlation of staining with Dukes’staging.
Conclusions: There was a clear discrimination between malignant neoplasm and normal cells. Correlation of cytoplasmic and nuclear staining with molecular stages of the adenoma-carcinoma sequence is planned. |
| Keywords:
biomarker | colorectal cancer | P2X receptor |
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