| Clinical Significance of Perineural Invasion in Colorectal Cancer |
| Moo Jun Baek, Hyung Wook Lee, Tae Sung Ahn, Sung Woo Cho, Eung Jin Shin, Nae Kyung Park, Moon Soo Lee, Chang Ho Kim |
| Department of Surgery, Soonchunhyang University College of Medicine, Korea. |
| 대장암에서 신경주위 암 세포 침습의 임상적 의의 |
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백무준, 이형욱, 안태성, 조성우, 신웅진, 박내경, 이문수, 김창호 |
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순천향대학교 |
| Corresponding Author:
Moo Jun Baek ,Tel: +82-41-570-3633, Fax: +82-41-571-0129, Email: ssurge@sch.ac.kr |
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Received: May 1, 2012; Accepted: June 23, 2012. |
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| ABSTRACT |
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Purpose : Perineural invasion (PNI) is widely known to be correlated with poor survival in many type of malignancy
but the connection between perineural invasion of colorectal cancer and the prognosis has not yet been clearly
confirmed. Therefore, we examined perineural invasion in colorectal cancers and investigated its relationship to
clinicopathological features such as tumor staging, lymph node metastasis, vascular invasion, lymphatic invasion
and patient’s prognosis in this study
Methods : The subjects were 148 colorectal cancer patients who underwent surgical resection in OOO. The
pathologists who were not aware of the prognosis of the patients reexamined the existing biopsy results and
reevaluated the perineural invasion. The presence of perineural invasion and the other clinicopathological factors
were compared and the statistical significance of the correlation between these was examined.
Results : Perineural invasion was confirmed in less than 10% of the patients in the initial biopsy results. However, it
was confirmed in 20.9% of the patients reevaluating the biopsy. Perineural invasion in colorectal cancer was found
to be unrelated to the T stage of the patients (p=0.114). On the other hand, perineural invasion appeared to be
strongly related to lymph node metastasis of colorectal cancer (p<0.001) and lymphatic and vascular invasion was
more common in the patients with perineural invasion (p=0.001). Moreover, perineural invasion seemed to be
related to the stage of cancer (p<0.001) and patient’s survival (p<0.05). Nevertheless, it was neither correlated to
the level of differentiation nor to the distant metastasis since perineural invasion was expressed in 21% of the
patients with distant metastasis and in 20% of the patients without distant metastasis.
Conclusion : The correlation of perineural invasion in colorectal cancer to the clinicopathologic factors such as
lymph node metastasis, lymphatic invasion, vascular invasion and the stage of disease were confirmed. And
perineural invasion was significantly correlated with patient’s survival. This is thought to be that perineural
invasion can be a prognostic factor of colorectal cancer and it should be utilized planning adjuvant therapy for
colorectal cancer patients. |
| Keywords:
Perineural invasion | Colorectal cancer | Prognostic factor |
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