Surgical outcomes and prognostic factors of gastric cancer surgery in octogenarians

Article information

2019;15(2):112-120
Publication date (electronic) : 2019 December 31
doi : https://doi.org/10.14216/kjco.19020
Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
Correspondence to: Byoung Jo Suh, Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea, Tel: +82-51-797-0656, Fax: +82-51-797-0260, E-mail: oltx62@hanmail.net
Received 2019 September 23; Revised 2019 October 27; Accepted 2019 November 12.

Abstract

Purpose

As the Korean population ages, an increasing number of elderly patients with gastric cancer are undergoing surgical resection. The aim of this study was to analyze the surgical outcomes and prognostic factors after gastric cancer surgery for patients 80 years of age or older.

Methods

We analyzed the medical records of 720 patients with gastric cancer who underwent gastrectomy from March 2010 to December 2014 retrospectively. Patients were divided into two groups: octogenarians (age ≥80 years, n=46) and non-octogenarians (age <80 years, n=674). We evaluated clinicopathologic data including postoperative morbidity, mortality, and 5-year survival rate.

Results

The rate of curative resection was not different between the two groups. The American Society of Anesthesiology score was significantly higher in the octogenarians (P<0.05). Octogenarians exhibited poorer performance scale scores, higher comorbidities, and more advanced TNM stages than non-octogenarians. There was no difference in surgical resection margins between the two groups. In addition, octogenarians suffered from more postoperative morbidity and mortality than non-octogenarians. In the analysis of risk factors of survival after gastrectomy for octogenarians, advanced TNM stage and dose of transfusion were independent risk factors. Overall survival was significantly lower in octogenarians than non-octogenarians. There was no difference in the disease-specific survival for each stage of cancer after adjustment for tumor stage.

Conclusion

Octogenarians had more preoperative risk factors and postoperative morbidity and mortality, but cancer-specific survival was comparable with non-octogenarians. Careful preoperative evaluation, thorough resection, and attentive postoperative care can improve the overall survival of octogenarians with gastric cancer.

INTRODUCTION

Gastric cancer is the fifth most common cancer worldwide and the third leading cause of cancer-related deaths. It also has the highest incidence in East Asian, Central Asian, and Latin American populations. Among these, Korean men have the highest incidence [1]. As lifespans continue to increase, 10% to 20% of patients with gastric cancer are now over 80 years of age in developed countries [2]. In Japan, in 2009, 22.7% of the population were over 65 years old and 6.2% were over 80 years old, compared with only 5.7% and 0.7% in 1960, respectively [3]. In the United States, octogenarians (age ≥80 years) constitute 14% of the population aged 60 years or older, but by 2050, it is anticipated that 20% of the older population will be 80 years old or older.

As the elderly population continues to increase, it is concerning that more than 50% of gastric cancers are observed in the elderly [4]. In Europe in 1990, the peak of gastric cancer incidence was observed among populations aged 85 or more [5]. Patients in this age group have declining organ capacity and might have comorbidities such as cardiovascular disease and pulmonary dysfunction, so deciding to perform a gastrectomy in elderly patients must be done carefully by assessing the patients’ tolerance of surgical stress. Radical gastrectomy in elderly patients has an increased risk of morbidity and mortality, but there is some evidence that elderly patients can safely undergo such an operation [6]. Thus, it remains controversial whether the appropriate surgical procedures for treating gastric cancer should be the same in elderly and non-elderly patients. In this study, we evaluated the clinicopathologic findings and surgical outcomes of gastric cancer in octogenarians and non-octogenarians and investigated risk factors for postoperative complications and survival in octogenarians with gastric cancer.

METHODS

Patients

We collected data retrospectively from 720 consecutive patients who underwent gastrectomy for gastric cancer from March 2010 to December 2014 at Haeundae Paik Hospital, Inje University of Korea. Patients with palliative procedures such as bypass surgery or exploratory laparotomy were excluded. We divided the patients into two groups: octogenarians, consisting of patients aged 80–90 years (n=46) and non-octogenarians consisting of patients under 80 years of age (n=674).

All patients underwent subtotal gastrectomy or total gastrectomy with lymph node dissection (D1+ or D2) according to the guidelines of the Japanese Research Society for Gastric Cancer [7]. The cancer stage and histopathologic classification were based on the seventh edition of the American Joint Committee on Cancer staging system [8]. The clinicopathologic features included were age, sex, body mass index, comorbidities, smoking, American Society of Anesthesiology (ASA) risk, type of operation, tumor location, number of tumors, depth of invasion, lymph node metastasis, TNM 7th stage, the extent of lymphadenectomy, number of retrieved lymph nodes, surgical resection margin, blood loss, perioperative transfusion, dose of transfusion, operation time, and days of hospital stay. The postoperative complications were classified as either surgically or medically induced. Wound infection, intra-abdominal fluid collection, anastomotic leakage, anastomotic stenosis, postoperative bleeding (intra-abdominal, intraluminal), intestinal obstruction (one patient required readmission for additional treatment), and ileus were classified as surgically induced, while pulmonary disease, cardiovascular disease, hepatic disease, endocrine disease, and systemic infections were classified as medically induced. Late complications, including anemia and dumping syndrome, were not included in this study. Surgical mortality was defined as postoperative death from any cause within 30 days of surgery. Postoperative adjuvant chemotherapy was administered according to tumor stage, physical condition, and patient compliance. Adjuvant chemotherapy consisted of either TS-1 or capecitabine plus oxaliplatin (XELOX). All patients were followed up every 6 months for 5 years after surgery and then every year thereafter. Physical examination, an assay of tumor markers, routine laboratory tests, imaging by postoperative stomach computed tomography, and esophagogastroduodenoscopy (EGD) was performed during the regular follow-up period. Recurrence was diagnosed by EGD or radiologic examination, and was defined as loco-regional (site of the primary tumor or loco-regional lymph node), systemic (hematogenous metastasis, peritoneal carcinomatosis, or distant lymph nodes) or mixed (both distant and loco-regional). The median follow-up period was 51.0 months (range, 0.1–103.0 months). Based on follow-up data, we calculated the overall survival (OS) and disease-specific survival (DSS) rates until December 2018.

Long-term outcome was defined as OS and DSS at each stage. Cause of death was classified as recurrence of gastric cancer, other disease (pulmonary, cardiac, hepatic, cerebral, and renal disease), or other cancer. The study protocol was approved by the Institutional Review Board of Inje University Haeundae Paik Hospital (HPIRB 2019-02-020-001). The informed consent was waived.

Statistical analysis

The clinical and pathological characteristics of the two groups were compared using the chi-square or Fisher exact test for continuous data and the independent t-test or the Mann–Whitney U-test for categorical data. OS was estimated by the Kaplan-Meier method and the log-rank test was used to compare survival curves. OS was defined as the time from operation until death. DSS was defined as the time from operation until death only for tumor relapse. Multivariate analysis for independent risk factors was performed using the logistic regression test, and Cox proportional hazard models were used to obtain the hazard ratio. A P-value <0.05 was considered to indicate a statistically significant difference with a 95% confidence interval. All statistical calculations were performed with the aid of SPSS software version 25.0 (IBM Corp., Armonk, NY, USA).

RESULTS

The demographic and clinicopathologic characteristics of the two groups are shown in Table 1. Of the 720 patients, 46 (6.4%) were octogenarians. The median age was 82.6±2.7 years (range, 80–90 years) among the octogenarians and 60.4±11.3 years (range, 23–79 years) among non-octogenarians. The male to female ratio was 1.78:1 in non-octogenarians and 1.3:1 in octogenarians. Octogenarians had more preoperative comorbidity than non-octogenarians (78.3% vs. 51.9%). Moreover, the preoperative ASA score was significantly higher in octogenarians due to increased comorbidities compared to non-octogenarians (P<0.001). There were no differences in the type of gastrectomy or the extent of lymphadenectomy between the two groups. Operation time was shorter in octogenarians (193.3±59.5 minutes vs. 230.8±69.1 minutes, P<0.001). The average number of retrieved lymph nodes was 41.2±14.4 in octogenarians and 46.8±17.7 in non-octogenarians. The volume of blood loss was similar in both groups. Perioperative transfusion was performed more often in octogenarians compared to non-octogenarians (63.0% vs. 23.4%, P<0.001) and the dose of transfusion was significantly different between the two groups. The hemoglobin of patients who received perioperative transfusion was divided before and after surgery, but there was no significant difference (11.7±1.9 g/dL vs. 11.2±1.4 g/dL, P=0.085 and 11.2±1.4 g/dL vs. 11.1±1.4 g/dL, P=0.587) (Table 2). Hospital stay was longer in octogenarians compared to non-octogenarians (19.5±11.1 days vs. 14.7±5.8 days, P=0.005).

Clinicopathologic characteristics of the patients

Preoperative and postoperative hemoglobin of patients who received perioperative transfusion

Table 3 compares the preoperative comorbidities of both groups. Hypertension was the most common comorbidity of the two groups (29.4% vs. 50.0%).

Preoperative comorbidity in each group

The proportions of patients who experienced postoperative complications were 30.4% in the octogenarians and 8.5% in the non-octogenarians (P<0.001). The most frequent complication in octogenarians was anastomosis leakage, which occurred significantly more often than in non-octogenarians (P<0.001) (Table 4).

Postoperative morbidities in each group

The long-term outcome of the cause of death between the two groups is shown in Table 5. Surgical mortality was significantly different between the two groups.

Long-term outcome of cause of death

OS was significantly lower in octogenarians than in non-octogenarians (P<0.001) (Fig. 1). However, DSS was comparable between the two groups (P=0.728) (Fig. 2). When adjusted for TNM 7th classification, there were no statistically significant differences observed between patients with stage Ia (P=0.805), stage IIa (P=0.515), stage IIb (P=0.246), stage IIIa (P=0.594), stage IIIb (P=0.820), stage IIIc (P=0.206), or stage IV (P=0.854) (Fig. 3).

Fig. 1

Overall survival rate of octogenarians and non-octogenarians after surgery.

Fig. 2

Disease-specific survival rate of octogenarians and non-octogenarians after surgery.

Fig. 3

Disease-specific survival rate of each age group according to TNM stage. (A) Stage Ia, (B) stage IIa, (C) stage IIb, (D) stage IIIa, (E) stage IIIb, and (F) stage IIIc, (G) stage IV.

Univariate and multivariate analyses were performed to reveal prognostic factors for octogenarians undergoing gastrectomy. The univariate analysis revealed that the depth of invasion (≥pT3), lymph node metastasis (positive), TNM stage (≥III), postoperative complications, and dose of transfusion (≥5 units) statistically significantly affected prognosis in octogenarians. Meanwhile, the multivariate analysis revealed that TNM stage (≥III) and dose of transfusion (≥5 units) were independent prognostic factors (Table 6).

Univariate and multivariate analysis of prognostic factors for octogenarians undergoing gastrectomy

DISCUSSION

As the longevity of people has increased in recent years, the proportion of gastric cancer in elderly patients has also steadily increased [9]. In Korea in 2016, gastric cancer was the most commonly diagnosed cancer overall and the most commonly diagnosed cancer among men age 35 to 64 years. In people over 65, gastric cancer was the second most diagnosed cancer in both sexes. However, the 5-year relative survival rates for gastric cancer have increased steadily since 1993 [10].

Usually, postoperative morbidity and mortality after gastrectomy for curative intent might be higher in elderly patients than in young patients because elderly patients generally have more preoperative comorbidity and decreased organ function [11,12]. Although the resection rate for elderly patients with gastric cancer has historically been very low in Western countries compared with eastern countries like Japan [13], recent advanced surgical and anesthetic techniques have reduced perioperative complications and improved surgical outcomes in elderly patients [14]. Therefore, the issue of whether gastric cancer surgery should be performed in elderly patients is a major concern for both surgeons and patients and their families [10,15,16].

Arai et al. [17] reported that a distal shift in cancer location increased the multiplicity of gastric cancer with advancing age and that, as the tumors grow, histological diversity is also increased. Liang et al. [18] reported that elderly patients had characteristics such as larger tumor size, more histological differentiation, a higher proportion of tumors located in the upper third of the stomach, and advanced TNM stage. In this study, octogenarians had a higher male to female ratio, deeper invasion, more frequent lymph node metastasis, a more advanced TNM 7th stage, more perioperative transfusions with higher doses, and a longer hospital stay. These findings might suggest that octogenarians are more likely to succumb to postoperative complications due to preoperative comorbidities and frailty. Some studies have reported significantly higher rates of postoperative complications and poorer survival rate in elderly patients because of preoperative comorbidities or unrecognized frailty [19,20]. A formal comprehensive geriatric assessment including age, cognitive function, poor nutritional status, history of falls, depressive mood, and anemia showed predictive value for surgical outcomes [2]. In this study, octogenarians had longer hospital stays and higher postoperative morbidity and mortality rates than those of non-octogenarians.

In gastric cancer patients, securing a negative surgical resection margin and adequate lymph node dissection during gastrectomy is an important factor for OS [21,22]. In this study, octogenarians were more likely to have a shorter operation time and fewer retrieved lymph nodes, although there was no statistically significant difference in either the surgical negative margin (100% vs. 98.5%, respectively) or the D1+/D2 dissection ratio (23.9%:25.9% vs. 76.1%:73.9%, respectively). However, the OS benefit of D2 lymph node dissection was rarely seen in elderly patients with comorbidities [23,24]. Therefore, more attention should be paid to preoperative evaluation and treatment of other comorbidities to improve gastrectomy outcomes in octogenarians.

Many studies have reported that the depth of invasion, lymph node metastasis, and tumor stage were independent prognostic factors for surgical outcomes in elderly patients with gastric cancer [25,26]. In this study we showed that TNM stage and dose of transfusion were independent prognostic factors for octogenarians undergoing gastrectomy. Our previous study showed that postoperative transfusion was a significant risk factor for postoperative complications in elderly gastric cancer patients undergoing gastrectomy [27]. Perioperative transfusion criteria in our institution: preoperative and postoperative hemoglobin <9.0, intraoperative hemoglobin <10.0. In this study, there was no statistically significant difference in the preoperative and postoperative hemoglobin of patients who received perioperative transfusions. Also, there was no statistical difference between the two groups when comparing the preoperative/intraoperative/postoperative transfusions. However, the intraoperative transfusion rate was higher in octogenarians (51.7% vs. 48.1%, P=0.720). Because the connective tissue and lymph nodes of elderly patients are more friable than those of non-elderly patients, elderly patients are likely to have increased bleeding and require more transfusions. There was no statistical difference in the amount of intraoperative bleeding, which may be due to the inaccurate measurement of intraoperative bleeding. Nevertheless, we performed an extend lymph node dissection for advanced gastric cancer patients regardless of age, because D2 dissection is standard at our institute. Transfusions are associated with risks including transfusion-related acute lung injury, multiple organ failure, graft-versus-host disease, and infectious disease transmission [28]. Some articles have reported that perioperative transfusions are associated with higher postoperative complications [29,30].

DSS for octogenarians was comparable with that of non-octogenarians, although postoperative morbidity and mortality rates were higher in octogenarians. To improve the survival rate of octogenarians undergoing gastrectomy, it is important to make the diagnosis as early as possible and select eligible patients carefully.

There were some limitations of this study. First, this study was retrospective in design, so several minor events might have been missed during data extraction. In our previous study, we compared the prognostic factors of patients over 70 years old. Therefore, we think it would be a good idea to compare generational results with further research. Second, this study was conducted in a single institution, and the small population of elderly patients may not reflect the results of other institutions or countries.

In conclusion, octogenarians had a lower OS rate but their DSS rate was comparable with that of non-octogenarians. The TNM stage and dose of transfusions were independent prognostic factors; neither ASA nor comorbidities had an impact on prognosis. Therefore, age should not be considered as the only factor in gastric cancer surgery in elderly patients.

Also, early detection is important to achieve long-term survival in gastric cancer patients.

Notes

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

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Article information Continued

Fig. 1

Overall survival rate of octogenarians and non-octogenarians after surgery.

Fig. 2

Disease-specific survival rate of octogenarians and non-octogenarians after surgery.

Fig. 3

Disease-specific survival rate of each age group according to TNM stage. (A) Stage Ia, (B) stage IIa, (C) stage IIb, (D) stage IIIa, (E) stage IIIb, and (F) stage IIIc, (G) stage IV.

Table 1

Clinicopathologic characteristics of the patients

Characteristic Non-octogenarian (n=674) Octogenarian (n=46) P-value
Age (yr) 60.4±11.3 82.6±2.7 <0.001a)

Sex 0.302
 Male 432 (64.1) 26 (56.5)
 Female 242 (35.9) 20 (43.5)

BMI (kg/m2) 23.8±3.3 22.3±3.3 0.809

Comorbidity 0.001a)
 Yes 350 (51.9) 36 (78.3)
 No 324 (48.1) 10 (21.7)

Smoking 0.055
 Yes 173 (25.7) 6 (13.0)
 No 501 (74.3) 40 (87.0)

ASA score <0.001a)
 1 200 (29.7) 0
 2 402 (59.6) 30 (65.2)
 3 72 (10.7) 16 (34.8)

Type of operation 0.774
 Subtotal gastrectomy 515 (76.4) 36 (78.3)
 Total gastrectomy 159 (23.6) 10 (21.7)

Tumor location 0.522
 Upper thirds 113 (16.8) 5 (10.9)
 Middle thirds 186 (27.6) 12 (26.1)
 Lower thirds 365 (54.2) 29 (63.0)
 Whole 10 (1.5) 0

No. of tumors 0.889
 Single 652 (96.7) 45 (97.8)
 Multiple 22 (3.3) 1 (2.2)

Depth of invasion 0.033a)
 pT1 405 (60.1) 17 (37.0)
 pT2 73 (10.8) 8 (17.4)
 pT3 110 (16.3) 10 (21.7)
 pT4 86 (12.7) 11 (23.9)

Lymph node metastasis 0.004a)
 N0 (0) 444 (65.9) 18 (39.1)
 N1 (1–2) 63 (9.3) 9 (19.6)
 N2 (3–6) 56 (8.3) 6 (13.0)
 N3a (7–15) 60 (8.9) 9 (19.6)
 N3b (>15) 51 (7.6) 4 (8.7)

TNM stage (7th) 0.007a)
 Ia 368 (54.6) 13 (28.3)
 Ib 62 (9.2) 5 (10.9)
 IIa 60 (8.9) 8 (17.4)
 IIb 38 (5.6) 5 (10.9)
 IIIa 30 (4.5) 1 (2.2)
 IIIb 47 (7.0) 3 (6.5)
 IIIc 52 (7.7) 9 (19.6)
 IV 17 (2.5) 2 (4.3)

Extent of lymphadenectomy 0.742
 D1+ 176 (26.1) 11 (23.9)
 D2 498 (73.9) 35 (76.1)

No. of retrieved lymph nodes 46.8±17.7 41.2±14.4 0.037a)

Resection margin 0.405
 Negative 664 (98.5) 46 (100.0)
 Positive 10 (1.5) 0

Blood loss (mL) 162.7±122.4 163.3±63.3 0.974

Perioperative transfusion <0.001a)
 Yes 158 (23.4) 29 (63.0)
 No 516 (76.6) 17 (37.0)

Dose of transfusion (unit) 0.9±2.5 2.8±3.7 <0.001a)

Operation time (min) 230.8±69.1 193.3±59.5 <0.001a)

Hospital stay (day) 14.7±5.8 19.5±11.1 0.005a)

Values are presented as the mean±standard deviation or number (%).

BMI, body mass index; ASA, American Society of Anesthesiology.

a)

P<0.05.

Table 2

Preoperative and postoperative hemoglobin of patients who received perioperative transfusion

Hemoglobin Non-octogenarian (n=158) Octogenarian (n=29) P-value
Preoperative hemoglobin (g/dL) 11.7±1.9 11.2±1.4 0.085
Postoperative hemoglobin (g/dL) 11.2±1.4 11.1±1.4 0.587

Values are presented as the mean±standard deviation.

Table 3

Preoperative comorbidity in each group

Comorbidity Non-octogenarian (n=674) Octogenarian (n=46) P-value
None 328 (48.7) 9 (19.6) <0.001a)
Hypertension 198 (29.4) 23 (50.0) 0.003a)
Cardiovascular disease 41 (6.1) 4 (8.7) 0.521
Pulmonary disease 33 (4.9) 3 (6.5) 0.495
Diabetes mellitus 33 (4.9) 1 (2.2) 0.717
Liver disease 18 (2.7) 2 (4.3) 0.370
Renal disease 0 1 (2.2) 0.064
Others 23 (3.4) 3 (6.5) 0.227

Values are presented as number (%).

a)

P<0.05.

Table 4

Postoperative morbidities in each group

Complications Non-octogenarian (n=674) Octogenarian (n=46) P-value
Surgical complications 44 (6.5) 6 (13.0) 0.093
 Wound infection 2 (0.3) 0 1.000
 Fluid collection 7 (1.0) 0 1.000
 Leakage 8 (1.2) 4 (8.7) 0.005a)
 Stenosis 4 (0.6) 1 (2.2) 0.282
 Intra-abdominal bleeding 4 (0.6) 0 1.000
 Intraluminal bleeding 3 (0.4) 0 1.000
 Intestinal obstruction 4 (0.6) 0 1.000
 Ileus 12 (1.8) 1 (2.2) 0.579

Medical complications 15 (2.2) 8 (17.4) <0.001a)
 Pulmonary disease 4 (0.6) 3 (6.5) 0.007a)
 Cardiovascular disease 1 (0.1) 2 (4.3) 0.012a)
 Hepatic disease 2 (0.3) 2 (4.3) 0.022a)
 Endocrine disease 1 (0.1) 0 1.000
 Systemic infection 0 1 (2.2) 0.064
 Others 6 (0.9) 0 1.000
Total complications 59 (8.5) 14 (30.4) <0.001a)

Values are presented as number (%).

a)

P<0.05.

Table 5

Long-term outcome of cause of death

Non-octogenarian (n=674) Octogenarian (n=46) P-value
Surgical (30 day) mortality 1 (0.1) 3 (6.5) 0.001a)
Alive 557 (82.8) 22 (51.2) <0.001a)
Recurrence of gastric cancer 80 (11.9) 3 (6.5) 0.346
Pulmonary disease 6 (0.9) 7 (15.2) <0.001a)
Cardiac disease 2 (0.3) 1 (2.2) 0.180
Hepatic disease 1 (0.1) 3 (6.5) 0.001a)
Cerebral disease 2 (0.3) 1 (2.2) 0.180

Values are presented as number (%).

a)

P<0.05.

Table 6

Univariate and multivariate analysis of prognostic factors for octogenarians undergoing gastrectomy

Characteristic Univarate analysis Multivariate analysis


Overall survival rate P-value HR (95% CI) P-value
Sex 0.181
 Male 38.1
 Female 60.0

ASA score 0.235 0.494 (0.179–1.367) 0.175
 2 56.3
 3 31.3

Comorbidity 0.206 3.447 (0.758–15.666) 0.109
 No 66.7
 Yes 42.7

Type of operation 0.442
 Subtotal gastrectomy 49.5
 Total gastrectomy 40.0

Depth of invasion 0.009a) 1.664 (0.635–4.363) 0.300
 pT1 & pT2 63.1
 pT3 & pT4 28.6

Lymph node metastasis 0.002a) 3.230 (0.802–13.017) 0.099
 Negative 77.4
 Positive 28.6

TNM stage <0.001a) 3.276 (1.034–10.385) 0.044a)
 I & II 67.2
 III & IV 6.7

Lymph node dissection 0.294
 D1+ 62.3
 D2 42.7

Complication 0.013a) 1.934 (0.730–5.121) 0.184
 No 55.6
 Yes 28.6

Dose of transfusion (unit) <0.001a) 1.313 (1.132–1.523) <0.001a)
 0–4 56.3
 ≥5 11.1

HR, hazard ratio; CI, confidence interval; ASA, American Society of Anesthesiology.

a)

P<0.05.