Rapid progression of sarcomatoid carcinoma of the common bile duct

Article information

2019;15(1):40-45
Publication date (electronic) : 2019 June 30
doi : https://doi.org/10.14216/kjco.19008
1Department of Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
2Department of Pathology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
Correspondence to: Young Chul Yoon, Department of Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 56 Dongsu-ro, Bupyeong-gu, Incheon 21431, Korea, Tel: +82-32-280-5862, Fax: +82-32-280-5988, E-mail: k07yyc@catholic.ac.kr
Received 2019 May 18; Revised 2019 June 8; Accepted 2019 June 10.

Abstract

Since sarcomatoid carcinoma in the common bile duct (CBD) is rarely reported, the clinical course and prognosis after surgery are unclear. We report a case of a patient who died within 1 month after surgery due to rapid tumor progression. A 65-year-old woman had abdominal pain with jaundice. She was diagnosed with CBD cancer and underwent pancreatoduodenectomy. Pathologic examination revealed sarcomatoid carcinoma. There was no postoperative complication, but multiple liver metastasis was diagnosed on computed tomography at 7 days after surgery. Also, the patient complained of abdominal pain and had jaundice with elevated liver enzyme on the 14th postoperative day. Her general condition was getting worse and she died of hepatic failure 23 days after surgery. We report a case of sarcomatoid carcinoma of the CBD that progressed very rapidly. Further research and case reports are needed to establish proper diagnostic and treatment tools.

INTRODUCTION

Sarcomatoid carcinoma is a rare malignant spindle cell neoplasm in which epithelial differentiation may be demonstrated by immunohistochemical or ultrastructural studies [1,2]. These tumors have been reported in many different organs, including esophagus, lung, liver, stomach, gallbladder, pancreas, small intestine, urinary tract, and uterus. Though well defined, histopathological sarcomatoid carcinoma occurring in the common bile duct (CBD) is extremely rare; and its clinical behavior and prognosis are unclear. Generally, sarcomatoid carcinoma is known to have poorer prognosis than carcinoma. There is a few report where bile duct sarcomatoid carcinoma has better prognosis than in gallbladder carcinoma [3]. We report a case of sarcomatoid carcinoma in the CBD that progressed rapidly after surgery.

This case report was approved by the Institutional Review Boards of Catholic University Incheon St. Mary’s Hospital (IRB No. OC19ZESI0026) and written in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained.

CASE REPORT

A 65-year-old female patient was visited for further management of jaundice with vague abdominal pain. She had elevated liver enzymes (total bilirubin, 7.9 mg/dL; aspartate aminotransferase, 231 U/L; alanine aminotransferase, 311 U/L; alkaline phosphate, 143 U/L). Her tumor marker levels were mildly elevated in carbohydrate antigen 19-9 (50.5 U/mL) and otherwise normal (alpha-fetoprotein, 2.85 ng/mL; carcinoembryonic antigen, 1.16 ng/mL). Contrast enhanced chest-abdomen-pelvis computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) were performed for diagnosis and oncologic staging. CT and ERCP showed longitudinal narrowing in mid CBD (Fig. 1). Brush cytology smears from the distal bile duct showed atypical cell, suggesting adenocarcinoma. We did not perform liver magnetic resonance imaging because there was no suspicion of liver metastasis on CT. Preoperative imaging stage was T2 or T3N0M0. Two weeks after CT scan, we performed pancreatoduodenectomy. Intraoperatively, there were no suspicious findings of liver metastasis. The tumor in the specimen showed an infiltrative growth pattern and the size of the tumor was measured as 3.5×2.2×1.5 cm. Microscopic findings and special staining confirmed sarcomatoid carcinoma. There were no cancer cells in the margins of the retrieved specimen, and no cancer cells were found among the 17 removed lymph nodes. Her postoperative course was uneventful. However, multiple liver masses were found in abdominal CT, scanned routinely 1 week after surgery (Fig. 2). Liver biopsy confirmed liver metastasis. Because it was only 1 week after surgery, chemotherapy was not considered. The patient gradually became malnourished and complained of generalized pain. After 2 weeks post-surgery, liver enzyme elevated gradually and we performed CT scans repeatedly. There were multiple lung metastases as well as more aggravated multiple liver metastases (Fig. 3). Her condition worsened and she died on the 23rd day after surgery due to hepatic failure.

Fig. 1

(A, B) Computed tomography and endoscopic retrograde cholangiopancreatography (before surgery). White arrows illustrate bile duct sarcomatoid carcinoma, which protrudes longitudinally on bile duct.

Fig. 2

Computed tomography (1 week after surgery). Multiple liver metastases were found in abdominal computed tomography.

Fig. 3

Computed tomography (2 weeks after surgery). (A, B) Multiple lung and liver metastases were found in computed tomography. White arrows illustrate lung metastases.

Grossly, the tumor was a poorly-demarcated and periductal infiltrative mass, located in the distal CBD and extended to periductal soft tissue, pancreatic parenchyma, and peripancreatic soft tissue. Microscopically, the tumor was composed of components with variable histologic features. Adenocarcinoma component was focally identified with poorly-formed glandular structures and intracellular mucin (Fig. 4A). The majority of tumor cells were sarcomatoid; haphazardly arranged spindle cells in collagenous or myxoid background (Fig. 4B). Undifferentiated pleomorphic cells, poorly cohesive oval to epithelioid cells (Fig. 4C) and compactly-arranged clear cells were also frequently observed. Adenocarcinoma component was focally identified with poorly-formed glandular structures and intracellular mucin (Fig. 4A). Multinucleated giant cells were observed in liver metastasis (Fig. 4D). However, no heterologous sarcomatous elements were identified.

Fig. 4

Representative images of the tumor components. (A) Poorly-differentiated adenocarcinoma component with glandular structures and intracellular mucin, (B) spindle cell component with myxoid background and (C) oval and epithelioid component are observed. (D) In metastasis to liver, infiltrative tumor cells with multinucleated giant cell are observed (H&E, ×200).

On immunohistochemistry, tumor cells showed diffuse and strong positivity for both pan-cytokeratin and vimentin, regardless of histologic features (Fig. 5), while showing total negativity for desmin and smooth muscle actin.

Fig. 5

Immunohistochemical staining (×200). Vimentin positivity in oval and epithelioid component (A) and pan-cytokeratin positivity in spindle cell component (B).

DISCUSSION

Sarcomatoid carcinoma is an unusual malignant tumor and its clinical behavior has not yet been fully established. It is often confused with carcinosarcoma. Histologically, sarcomatous carcinoma and carcinosarcoma are completely different entities, but they are often confused because they exhibit similar histological features and clinical behavior [4]. They have aggressive clinical course characterized by local recurrences and metastasis.

Similar to carcinosarcoma in other organs, carcinosarcoma in the gallbladder also has a very poor prognosis. Median survival after surgical resection was 7 months and the reported 1-, 2-, and 3-year survival rates after surgery were 37.2%, 31.0%, and 31.0%, respectively [5]. Sarcomatoid carcinoma and carcinosarcoma of the bile duct represents very rare prevalence. To date, only 10 case reports have been reported of sarcomatoid carcinoma and carcinosarcoma in bile ducts in the English literature (Table 1) [3,614]. Tumors in the CBD may have a better prognosis owing to their polypoid nature that leads to earlier presentation as it obstructs the bile duct–in contrast to gallbladder sarcomatoid carcinoma, which usually presents as an infiltrative form [3,13]. We calculated the survival rate of bile duct sarcomatoid carcinoma and carcinosarcoma using cases reported so far. The overall 1-, 2-, and 3-year survival rates after surgery were 53.3%, 35.6% and 35.6%, respectively (Fig. 6). It showed better survival than gallbladder cases. However, prognosis was worse than other bile duct carcinoma. In almost all cases, where there were bile duct obstructive symptoms, early detection was possible, and survival rate was improved, as mentioned. But as for recurrence, bile duct sarcomatoid carcinoma and carcinosarcoma presents very poor prognosis.

Summary of clinicopathological characteristics in literature and current case

Fig. 6

Survival after surgical resection for sarcomatoid carcinoma and carcinosarcoma of the bile duct (n=11).

Throughout the reported case, we found recurrence within 2 months, and tumor progression was very rapid. However, there were no cases that progressed as rapidly as shown in our case. The cases reported so far mostly presented a polypoid pattern of the tumor in the CT or the pathology of the removed specimen (7 of 10 cases). Alternatively, in the present case, the tumor was flat on the bile duct and tumor growth showed an infiltrative pattern, usually shown in gallbladder carcinosarcoma. An infiltrative pattern may have poor prognosis compared with a polypoid pattern because polypoid types tend to arise earlier with obstruction of the bile duct and obstructive symptoms, which enable easier detection [14]. The present case shows very radical progression, thus having the possibility that multiple small hidden malignancies would go undetected preoperatively, as well as the histochemical features of a tumor, especially sarcomatoid cells, associated with poor prognosis. There are few references which support the reliability of chemotherapy and radiotherapy in cases of biliary sarcomatoid carcinoma [15]. At present, the first treatment option for sarcomatoid carcinoma and carcinosarcoma is surgery and complete resection of the tumor, similar to biliary carcinoma. However, as shown in this case, very poor prognosis and rapid progression to systemic metastasis proved that surgical resection is not adequate for radical cure in cases of biliary sarcomatoid carcinoma. Therefore, another treatment option should be researched, studied, and established. Still, however, the amount of cases of bile duct sarcomatoid carcinoma is tiny. Thus, more research and literature may be needed to establish proper diagnostic methods and treatment tools.

Sarcomatoid carcinoma of the bile duct may progress more rapidly than other carcinomas. However, there is currently no treatment other than complete surgical resection for as a cure. In preoperative examination, infiltrating type bile duct sarcomatoid carcinoma should be considered for rapid tumor progression after surgery.

Notes

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

References

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Article information Continued

Fig. 1

(A, B) Computed tomography and endoscopic retrograde cholangiopancreatography (before surgery). White arrows illustrate bile duct sarcomatoid carcinoma, which protrudes longitudinally on bile duct.

Fig. 2

Computed tomography (1 week after surgery). Multiple liver metastases were found in abdominal computed tomography.

Fig. 3

Computed tomography (2 weeks after surgery). (A, B) Multiple lung and liver metastases were found in computed tomography. White arrows illustrate lung metastases.

Fig. 4

Representative images of the tumor components. (A) Poorly-differentiated adenocarcinoma component with glandular structures and intracellular mucin, (B) spindle cell component with myxoid background and (C) oval and epithelioid component are observed. (D) In metastasis to liver, infiltrative tumor cells with multinucleated giant cell are observed (H&E, ×200).

Fig. 5

Immunohistochemical staining (×200). Vimentin positivity in oval and epithelioid component (A) and pan-cytokeratin positivity in spindle cell component (B).

Fig. 6

Survival after surgical resection for sarcomatoid carcinoma and carcinosarcoma of the bile duct (n=11).

Table 1

Summary of clinicopathological characteristics in literature and current case

Author (year) Sex/age (yr) Location Growth pattern (size) Surgery LN status Recurrence/site Prognosis
Loud et al. 1997 [6] F/35 Hilar Polypoid (NR) BD resection NR NR NR
Yoon et al. 2004 [7] M/78 Mid CBD Infiltrative (4.0 cm) PD 2/22 NR Died due to cardiac problem (5POD)
Kadono et al. 2005 [8] F/75 Mid CBD Infiltrative (NR) PD NR Local recurrence Died on 2 years due to local recurrence
Jang et al. 2005 [3] F/68 Distal CBD Polypoid (3.5 cm) PD NR No recurrence 1-Year DFS
Sodergren et al. 2005 [9] F/64 Hilar Polypoid (2.0 cm) BD resection NR No recurrence 5-Year DFS
Aurello et al. 2008 [10] F/73 Distal CBD Polypoid (2.6 cm) PD NR No recurrence 7-Month DFS
Tanaka et al. 2012 [11] M/71 Distal CBD Polypoid (7.5 cm) PD NR Liver metastasis Died on 10 months due to recurrence
Kumei et al. 2015 [12] F/73 Mid CBD Polypoid (6.5 cm) PD NR Liver metastasis Died on 6 months due to recurrence
Lee et al. 2016 [13] F/91 Hilar Polypoid (2.0 cm) BD resection NR Recurrence Died on 2 months due to recurrence
Zhang et al. 2017 [14] F/51 Distal CBD Infiltrative (3.8 cm) PD 0/12 No recurrence 3-Year DFS
Kim et al. (current study) F/65 Mid CBD Infiltrative (3.5cm) PD 0/17 Liver metastasis Died on 23 days due to recurrence

LN, lymph node; F, female; M, male; NR, not reported; BD, bile duct; CBD, common bile duct; PD, pancreatoduodenectomy; POD, postoperative day; DFS, disease-free survival.