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Korean Journal of Clinical Oncology > Volume 5(1); 2009 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2009;5(1): 15-20.         doi: https://doi.org/10.14216/kjco.09003
Clinicopathologic Characteristics of HER-2/neu Overexpressing Breast Cancer
Chul Nam Kim
Department of Surgery, Ilsan Paik Hospital, Inje Universitiy School of Medicine
HER-2/neu유전자 과발현 유방암의 임상병리학적 특성
김철남
인제대학교 의과대학 일산백병원 외과
Corresponding Author: Chul Nam Kim ,Tel: +82-31-910-7300, Fax: +82-31-910-7319, Email: cnkim@ilsanpaik.ac.kr
Received: April 20, 2009;  Accepted: May 19, 2009.
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ABSTRACT
Purpose : Clinicopathologic factors associated with prognosis in breast cancer patients have varied. HER-2/neu gene amplification and/or protein overexpression occur in 14-30% of all cases of breast cancer. Among clinicopathologic factors, HER-2/neu gene status has been suggested to be a significant prognostic indicator for breast cancer. The objective of this study was to determine whether HER-2/neu gene expression is associated with other clinicopathologic factors in breast cancer. Methods : The expression of HER-2/neu, Ki-67, p53, estrogen receptor and progesterone receptor was determined immunohistochemically and medical records were reviewed in 119 breast cancer patients, including 87 patients that demonstrated the absent of HER-2/neu expression and 32 patients with the present of HER-2/neu expression. Results : HER-2/neu expression was noted in 32 patients (26.9%) of the 119 breast cancer patients. Of the 87 patients(73.1%) with absent of HER-2/neu expression. There was a significant correlation between HER-2/neu expression and the nodal status (p=0.023), lymphovascular invasion( p=0.029), histologic grade(p=0.041), nuclear grade(p=0.001), estrogen receptor status(p=0.001) and progesterone receptor status(p=0.004). Nuclear grade was statistically significant association factor with HER-2/neu expression status independently in multivariate analysis.(p=0.041, relative risk 0.177, 95% CI 0.043-0.733) Conclusion : This study demonstrates the potential value of the lymph nodal status, lymphovascular invasion, histologic grade, nuclear grade and hormonal receptor status correlating with the status of HER-2/neu expression in human breast cancer.
Keywords: HER2/neu | Clinicopathologic feature | Breast cancer
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