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Korean Journal of Clinical Oncology > Article
REVIEW
Korean J Clin Oncol. 2009;5(1): 9-14.         doi: https://doi.org/10.14216/kjco.09002
Chemotherapy induced Cadiotoxicity
Ho-Joong Youn
Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
항암제 심독성
윤호중
가톨릭대학교 의과대학 순환기내과
Corresponding Author: Ho-Joong Youn ,Tel: +82-2-3779-1325, Fax: +82-2-3779-1374, Email: younhj@catholic.ac.kr
Received: April 26, 2009;  Accepted: May 19, 2009.
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ABSTRACT
Chemotherapy induced cardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and may cause severe morbidity in surviving cancer patients. The mechanism of anthracycline induced cardiotoxicity, relatively well established, seems to involve the free radicals formation and the apoptosis of myocytes. Prevention of cardiac toxicity can be achieved by control of the cumulative dose. Furthermore, addition of the iron chelator to anthracycline therapy has shown to be helpful. Other cytotoxic drugs such as the taxoids, 5-fluorouracil, cyclophosphamide and trastuzumab are associated with cardiotoxicity as well, although little is known about the possible mechanisms. The pathophysiology of these adverse effects is similarly heterogeneous and the identification of potential mechanisms is frequently difficult since the majority of cancer patients is not only treated with multiple anti-cancer drugs but might also be exposed to potentially cardiotoxic radiation therapy. Further research is warranted to understand the mechanism of chemotherapy induced cardiotoxicity and to develop strategies to avoid this side effect.
Keywords: Cardiotoxicity | Cancer | Chemotherapy
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