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Korean Journal of Clinical Oncology > Volume 6(2); 2010 > Article
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Korean J Clin Oncol. 2010;6(2): 84-89.         doi: https://doi.org/10.14216/kjco.10024
Asymptomatic pheochromocytoma
Jae ho Park1, Su Yun Choi1, Euy Young Soh2
1Department of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Koarea
2Department of Surgery, College of Medicine, Ajou University, Suwon, Korea
무증상 갈색 세포증
박재호1, 최수윤1, 소의영2
1한림대학교 의과대학 강동성심병원 외과학교실
2아주대학교 의과대학 외과학교실
Corresponding Author: Su Yun Choi ,Tel: +82-11-9877-1793, Fax: +82-2-2224-2570, Email: vamby@hanmaul.net
Received: November 20, 2010;  Accepted: December 23, 2010.
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ABSTRACT
Purpose: Approximately 1.6-30% of histologically proven pheochromocytomas are discovered by radiologic examination in the absence of symptoms. The aim of this study was to analyze the asymptomatic pheochromocytoma, to compare with typical pheochromocytoma. Meterials and
Methods: Fifty seven patients were reviewed who diagnosed pheochromocytoma at from 1988 to 2009. In the current study, we evaluated the characteristics of asymptomatic pheochromocytoma(AP) in 12 patients and compared with other 45 patients with typical pheochromocytoma(TP).
Results: Catecholamine overproduction was observed in 8 (66.7%) of AP patients. In particular, the mean values of biochemical parameters were lower in AP patients compared to TP patients, and single catecholamine overproduction was frequently observed. Despite preoperative preparation in forty seven patients, intraoperative hypertension occurred in thirty eight patients with spiking of >160 mmHg. In the asymptomatic group, there were 6 cases of spiking blood pressure higher then 160 mmHg. Intraoperative hemodynamic changes were not significantly different between AP and TP. During follow-up, there were five cases of recurrent disease (1 in the asymptomatic group and 4 in the typical group), and 1 case of recurrent disease was malignant.
Conclusion: Catecholamine screening in all patients with adrenal tumors is essential. Even in asymptomatic pheochromocytoma patients, there exists a likelihood of catecholamine overproduction, the surgical extirpation may offer an advantage. Such patients should be appropriately prepared before surgical intervention and regular and long term follow-up should also be considered to detect recurrent disease.
Keywords: asymptomatic pheochromocytoma | pheochromocytoma | cathecholamine overproduction
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