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Korean Journal of Clinical Oncology > Volume 6(2); 2010 > Article
REVIEW
Korean J Clin Oncol. 2010;6(2): 78-83.         doi: https://doi.org/10.14216/kjco.10023
Clinicopathologic Characteristics of Atypical Parathyroid Adenoma in Comparison with Parathyroid Adenoma and Carcinoma
Eun Mee Oh1, Kyu Eun Lee1, Su Jin Kim1, Yeo-Kyu Youn1, Kwi-Won Park1, Seung Keun Oh1, Kyeong Cheon Jung2, Young Tae Kim3, Kwang Hyun Kim4
1Department of Surgery, Seoul National University College of Medicine
2Department of Pathology, Seoul National University College of Medicine
3Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine
4Department of Otolarhinolaryngology, Seoul National University College of Medicine
부갑상샘종 및 부갑상샘 암에 대비되는 비정형 부갑상샘종의 임상병리학적 특성
오은미1, 이규언1, 김수진1, 윤여규1, 박귀원1, 오승근1, 정경천2, 김영태3, 김광현4
1서울대학교 의과대학 외과학교실
2서울대학교 의과대학 병리학교실
3서울대학교 의과대학 흉부외과교실
4서울대학교 의과대학 이비인후과교실
Corresponding Author: Yeo-Kyu Youn ,Tel: +82-2-2072-3447, Fax: +82-2-766-3975, Email: ykyoun@plaza.snu.ac.kr
Received: November 20, 2010;  Accepted: December 23, 2010.
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ABSTRACT
Purpose: The causes of primary hyperparathyroidism include parathyroid adenoma(PA), atypical parathyroid adenoma(AA) and parathyroid carcinoma(PC). This retrospective study aimed to find the clinicopathologic characteristics among these three diseases and unique characteristics of AA. Patients and Methods: One hundred patients who underwent parathyroidectomy due to primary hyperparathyroidism from January 1993 to December 2008 in Seoul National University Hospital were enrolled. The electronic medical records of 88 patients of PA, 10 patients of AA and 2 patients of PC were analyzed retrospectively.
Results: Male to female ratio was same in AA group but female predominance was found in PA group and male predominance in PC group. The mean age of AA group was similar to PA group but PC group was younger than other groups (PA: 50.18±15.07yrs, AA: 49.1±13.76yrs, PC: 44.0±18.39yrs, p= 0.832). The patients with PC showed higher preoperative serum calcium (PA: 11.90±1.46mg/dl, AA: 11.96±1.48mg/dl, PC: 14.25±2.76mg/dl, p= 0.091), ionized calcium (PA: 1.57±0.21mg/dl, AA: 1.54±0.34mg/dl, PC: 2.27mg/dl, p= 0.008) than other two groups and PA and AA showed similar results. PC group showed high parathyroid hormone levels than those of AA and PA (PA: 335.30±465.40pg/ml, AA: 992.88±612.30pg/ml, PC: 1221.00±227.69pg/ml, p< 0.001). Clinical symptoms were found more in PC group and majority of other two groups were found asymptomatic. PC group measured heavier and larger than AA and PA.
Conclusion: AA might be an intermediate stage between PA and PC. Close follow up might be needed after operation for AA.
Keywords: Primary Hyperparathyroidism | Parathyroid Carcinoma | Atypical Parathyroid Adenoma | Parathyroid Adenoma
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