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Korean Journal of Clinical Oncology > Volume 6(2); 2010 > Article
REVIEW
Korean J Clin Oncol. 2010;6(2): 26-30.         doi: https://doi.org/10.14216/kjco.10015
Clincopathologic features of Epstein-Barr virus-associated gastric carcinoma
Ji Young Kim1, Seung Jong Oh1, Jenny Jimmy Hong2, Cheong Ah Oh1, Dae Hoon Kim1, Young Sik Bae1, Min Gew Choi1, Kyoung Mee Kim3, Jae Hyung Noh1, Tae Sung Sohn1, Jae Moon Bae1, Sung Kim1
1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Surgical Oncology and Immunotherapy, National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, Maryland, U.S.A
3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Epstein-Barr 바이러스 양성 위암의 임상양상
김지영1, 오승종1, Jenny Jimmy Hong2, 오정아1, 김대훈1, 배영식1, 최민규1, 김경미3, 노재형1, 손태성1, 배재문1, 김성1
1성균관대학교 의과대학 외과학교실
2Surgical Oncology and Immunotherapy, National Cancer Institute, Surgery Branch, National Institutes of Health,Bethesda, Maryland, U.S.A.
3성균관대학교 의과대학 병리학교실
Corresponding Author: Tae Sung Sohn ,Tel: +82-2-3410-0498, Fax: +82-2-3410-6981, Email: ts.sohn@samsung.com
Received: November 20, 2010;  Accepted: December 23, 2010.
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ABSTRACT
Purpose: The purpose of this retrospective study is to examine the clinical and pathological features of Epstein-Barr virus (EBV) infection in patients with gastric cancer who underwent gastric resection. Subject and Method: Six hundred and forty patients with gastric cancer underwent gastric resection at Samsung Medical Center (Sungkyunkwan University School of Medicine) from September 2009 to January 2010. EBV was detected through in situ hydridization in these patients. Subsequent clinical and pathological features of EBV infection were analyzed and compared between the EBV-positive group and EBV-negative group.
Results: Of the 640 patients, 408 patients were male and and 232 patients were female. The average age was 55.3 years of age (range 26-82). In the EBV-positive group, 39 patients were male (90.7%) and 4 patients were female (9.3%) (p<0.001). Tumors were located in the upper one-third of the stomach (p<0.001) and had a mixed Lauren classification (p=0.010). Age, depth of tumor, size and shape of the tumor, degree of cancer differentiation, and lymph node metastasis were not statistically significant.
Conclusion: EBV-positive gastric cancer may be more prevalent in males with a predominance of a mixed intestinal and diffuse carcinomas of the Lauren classification (a mixed Lauren classification) that are located in the upper third of the stomach. However, additional factors that may influence the overall survival should be investigated in this specific group of patient population.
Keywords: Gastric cancer | Epstein-Barr virus
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