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Korean Journal of Clinical Oncology > Volume 6(1); 2010 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2010;6(1): 79-87.         doi: https://doi.org/10.14216/kjco.10011
Expression of ER, p53 and HER-2/neu in medullary carcinoma and infiltrating ductal carcinoma with medullary feature
Jong Eun Lee1, Jihyoun Lee1, Sun Wook Han1, Sang Ho Bae1, Gil Ho Gang1, Sung Yong Kim1, Moo Jun Baek1, Nae Kyeong Park1, Cheol Wan Lim1, Moon Soo Lee1, Chang Ho Kim1, Min Hyuk Lee1, Jee Hye Lee2, Hyun Duk Cho2, Mee Hye Oh2, Eui Han Kim2
1Department of Surgery, Soonchunhyang University, College of Medicine, Cheonan Hospital, Chungnam, Korea
2Department of Pathology, Soonchunhyang University, College of Medicine, Cheonan Hospital, Chungnam, Korea
전형적인 수질성 유방암과 수질암 모양을 가진 침윤성 유관암에서 Biologic marker인 ER, p53과 HER-2/neu의 발현 양상
이종은1, 이지현1, 한선욱1, 배상호1, 강길호1, 김성용1, 백무준1, 박내경1, 임철완1, 이문수1, 김창호1, 이민혁1, 이지혜2, 조현득2, 오미혜2, 김의한2
1순천향대학교 의과대학 외과학교실
2순천향대학교 의과대학 병리학교실
Corresponding Author: Sung Yong Kim ,Tel: +82-41-570-3636, Fax: +82-41-571-0129, Email: sykim@schca.ac.kr
Received: May 20, 2010;  Accepted: June 23, 2010.
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ABSTRACT
Purpose : Breast cancer with BRCA1 variation has similar microscopic appearance with medullary cancer, and has pushing margins. These cases are classified as infiltrating ductal carcinoma with medullary feature nowadays. In general, medullary cancer expresses positive p53 and negative HER-2/neu. Positive ER is related to good prognosis, and well differentiated cancer is related to positive predictive value. Based on these correlations, the study was designed to make differentiation between medullary cancer and infiltrating ductal carcinoma with medullary feature with expression of ER, p53, and HER-2/neu. Material and Methods : Specimen of 10 medullary cancer and 20 infiltrating ductal carcinoma with medullary feature, which were obtained from biopsy or operation at breast clinic in Soonchunhyang university Cheonan hospital underwent immunohistochemistry stain. Results : ER expression in medullary cancer was negative in 9 out of 10 cases. In infiltrating ductal carcinoma with medullary feature, it was negative in 14 out of 20 cases, and there was expression of grade 3 in 5 cases. Expression of p53 in medullary cancer was grade 1 in 5, and grade 3 in 5 among 10 cases. In infiltrating ductal carcinoma with medullary feature, it was grade 1 in 7, and grade 3 in 11 among 20 cases. The expression of HER-2/neu in medullary cancer was score 0 in 2, and score 3 in 4 among 10 cases. It was expressed as score 0 in 8, and score 3 in 10 among 20 cases with infiltrating ductal carcinoma with medullary feature. Conclusion : Expression of p53 and HER-2/neu was not useful in differentiating medullary cancer and infiltrating ductal carcinoma with medullary feature. ER was useful only in cases with positive ER expression. Microscopic findings of necrosis and stromal feature, or ultrasonographic findings of tumor margin was considered to be more valuable in discriminating the 2 diseases.
Keywords: Medullary | Breast Carcinoma | ER | p53 | Her-2/neu
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