| Home | E-Submission | Sitemap | Contact Us |  
logo
top_img
Korean Journal of Clinical Oncology > Volume 6(1); 2010 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2010;6(1): 40-46.         doi: https://doi.org/10.14216/kjco.10006
Clinical significance of tumor size in Gastric cancer
Hakjin Kim1, Youjin Jang1, Jonghan Kim1, Sungsoo Park1, Sungheum Park1, Seungjoo Kim1, Youngjae Mok1, Jongsuk Kim1, Jungmin Park2, Kyungsook Yang3
1Department of Surgery, Korea University College of Medicine, Seoul, Korea
2Department of Surgery, Joongang University College of Medicine, Seoul, Korea
3Department of Medical statistics, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Jongsuk Kim ,Tel: +82-2-920-5401, Fax: +82-2-928-1631, Email: chongsuk@korea.ac.kr
Received: May 20, 2010;  Accepted: June 23, 2010.
Share :  
ABSTRACT
Purpose: The objectives of this study were to investigate the impact of the tumor size on survival of gastric cancer patients who underwent curative resection and to evaluate relationships between tumor size and lymph node metastasis Materials and
Methods: We retrospectively studied 928 gastric cancer patients who underwent curative resection at Korea University Medical Center from 1992 to 2002. The cut-off value of tumor size was decied as the smallest value that showed significantly survival difference by COX proportional hazard model. The clinicopathological factors associated with tumor size were analyzed by using univatiate and multivariate analyses. And ROC curves were applied to measure cut-off value of tumor size that impact on lymph node metastasis.
Results: In COX proportional hazard model , the cut-off value of tumor size was 7cm that impact on prognosis. The tumor location, depth of invasion, lymph node metastasis, and cell differenciation were significantly different according to the tumor size. The Age, depth of invasion, tumor size and lymph node metastasis were independent prognostic factors by using multivariate analyses. In Releavance between the tumor size and lymph node metastasis, there were significant difference stage I, III, and whole patients group. And the each cut-off values were 1.5cm, 6cm, and 3.3cm
Conclusion: Tumor size was significant prognostic factor and important predictive value for lymph node metastasis in gastric cancer. So tumor size will useful parameter to perform EMR in early gastric cancer or to plan further management of advanced gastric cancer.
Keywords: Gastric cancer | tumor size | Lymph node metastasis | Clinical significance
Editorial Office
101-3304 Brownstone Seoul, 464 Cheongpa-ro, Jung-gu, Seoul 100-717, Korea
TEL : +82-2-393-2114   FAX : +82-2-393-1649   E-mail : ksco2004@paran.com

Copyright© Korean Society of Surgical Oncology. All rights reserved.                powerd by m2community
About |  Browse Articles |  Current Issue |  For Authors and Reviewers