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Korean Journal of Clinical Oncology > Volume 6(1); 2010 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2010;6(1): 19-26.         doi: https://doi.org/10.14216/kjco.10003
Expression of CD133 and CD24 as cancer stem cell markers in gastric cancers and comparison with prognostic factors
Yong Jin Kim1, Byung Sik Kim2, Sei Jin Jang3, Seung Sam Paik4
1Department of Surgery, Soonchunhyang University College of Medicine
2Department of Surgery, Ulsan University College of Medicine
3Department of Pathology, Ulsan University College of Medicine
4Department of Pathology, Hanyang University College of Medicine
Corresponding Author: Yong Jin Kim ,Tel: +82-2-709-9479, Fax: +82-2-795-1687, Email: yjkim@hosp.sch.ac.kr;yjgs1997@gmail.com
Received: May 20, 2010;  Accepted: June 23, 2010.
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ABSTRACT
Background: Cancer stem cells are a small population of tumor cells capable of self-renewal that give rise to all the components of a heterogenous tumor. Recently, this concept has been extended into various solid tumor after the first documentation in acute myeloid leukemia. CD133 and CD 24 were identified as cancer stem cell markers in other solid tumors such as breast cancer, brain cancer, pancreatic cancer and head and neck cancer. The aim of this study was to examine the expression CD133 and CD24 in gastric cancers. Furthermore, their clinical significance was evaluated.
Methods: Immunohistochemistry for CD133 and CD24 was performed on the tissue microarray of 388 gastric cancers. We retrospectively analysed the prognostic factors depending on the expression of CD133 and CD24.
Results: In gastric cancers, 251 of the 381 cases (66%) tested were positive for CD133 expression and 122 of the 386 cases (32%) tested were positive for CD24 expression. CD133 expression was more present in well differentiated cancer (p=0.003). However other prognostic factors were not related with CD 133 & CD24 expression The survival rate according to CD133 & CD24 expression was not significant.
Conclusions: We can figure out the potential presence of cancer stem cells in gastric cancers through confirming the positive expression of CD133 & CD24. However CD expressions didn°Øt show close relationship with prognostic factors and survival rate of gastric cancer.
Keywords: CD133 | CD24 | cancer stem cell | gastric cancer
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