| Home | E-Submission | Sitemap | Contact Us |  
logo
top_img
Korean Journal of Clinical Oncology > Volume 7(2); 2011 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2011;7(2): 81-87.         doi: https://doi.org/10.14216/kjco.11023
Clinical Implication of Peritoneal Cytology in Gastric Cancer
Kun Ho Roh, Ji Yeong An, Kyung Ho Pak, Jae-Ho Cheong, Sung Hoon Noh
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
위암에서의 복강 내 세포검사의 임상적 의의
노건호, 안지영, 박경호, 정재호, 노성훈
연세대학교 의과대학 외과학교실
Corresponding Author: Sung Hoon Noh ,Tel: +82-2-2228-2111, Fax: +82-2-313-8289, Email: sunghoonn@yuhs.ac
Received: September 23, 2011;  Accepted: October 20, 2011.
Share :  
ABSTRACT
Purpose : Peritoneal cytology has been reported to be a useful tool for the detection of peritoneal dissemination in several studies, and in the 7th edition of the AJCC staging, positive peritoneal cytology is classified as metastatic disease. This study evaluated the presence of free cancer cells through the peritoneal cytology in gastric cancer patients and analyzed their clinical and prognostic values. Materials and Methods : Total 125 gastric cancer patients who underwent gastrectomy with intraoperative peritoneal cytology were enrolled in this study, and they were categorized into two groups; cytology negative (Cy-) and cytology positive (Cy+). Results : 16 of total 125 patients (12.8%) were Cy+, and they had more advanced T, N, and M stages, as well as histologically undifferentiated carcinomas. The difference of the overall survival rates between Cy- and Cy+ group was not significant (p =0.106), but the disease free survival rates of patients with Cy+ were significantly shorter than those with Cy- (p <0.001). The survival curves of patients with positive cytology but no gross metastasis (Cy+/M0) showed no significant difference, compared to those with gross metastasis (M1) (p =0.076). Conclusions : Peritoneal lavage cytology may be a useful marker of tumor progression and a strong predictor of recurrence in gastric cancer patients. However, it should be questioned whether this novel marker is an independent prognosticator in survival and recurrence.
Keywords: gastric cancer | intraperitoneal free cancer cells | peritoneal cytology | prognosis
Editorial Office
101-3304 Brownstone Seoul, 464 Cheongpa-ro, Jung-gu, Seoul 100-717, Korea
TEL : +82-2-393-2114   FAX : +82-2-393-1649   E-mail : ksco2004@paran.com

Copyright© Korean Society of Surgical Oncology. All rights reserved.                powerd by m2community
About |  Browse Articles |  Current Issue |  For Authors and Reviewers