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Korean Journal of Clinical Oncology > Volume 7(2); 2011 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2011;7(2): 50-57.         doi: https://doi.org/10.14216/kjco.11019
The Relationship between the progression of colorectal cancer and microRNA polymorphisms
Ho Jin Chang1, Nam Keun Kim2, Young Joo Jeon2, Jong Woo Kim1
1Department of Surgery, School of Medicine, CHA University, Seongnam, South Korea
2Institute for Clinical Research, School of Medicine, CHA University, Seongnam, South Korea
대장암의 진행과 microRNA 유전자 다양성과의 관계
장호진1, 김남근2, 전영주2, 김종우1
1차 의과학 대학교, 외과학 교실
2차 의과학 대학교, 임상연구소
Corresponding Author: Jong Woo Kim ,Tel: +82-31-780-5250, Fax: +82-31-780-5259, Email: kjw@cha.ac.kr
Received: September 23, 2011;  Accepted: October 20, 2011.
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ABSTRACT
Purpose : MicroRNA(miRNA) is related not only with basic biologic process but with regulatory functions of diverse diseases including cancer. Although it is non-coding RNA of small nucleotides(18~23), nucleotide variation within primary(pri)- or precursor(pre)-miRNA might affect the mature process of miRNA and can cange it. And then we aim to elucidate the relationship between 4 kinds of pre-miRNA and clinical progress of colorectal cancer such as tumor stage, depth of invasion and regional lymph nodes metastasis. Methods : DNA was extracted from blood samples of 160 patients who underwent operation on colorectal cancers during recent 2 years and has-mir-146aC>G, has-mir-149T>C, has-mir-196a2T>C and has-mir-499A>G polymorphisams were genotyped by PCR-RFLP. Results : There was no relationship between the polymorphism distributions of 4 kinds of pre-miRNA and any clinical progresses of colorectal cancer. Conclusion : Although we were unable to find out significant relation between two categories, further active studies with miRNAs and cancers shoud be carried on.
Keywords: MicroRNA | polymorphism | Colorectal cancer
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