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Korean Journal of Clinical Oncology > Volume 7(1); 2011 > Article
REVIEW
Korean J Clin Oncol. 2011;7(1): 47-51.         doi: https://doi.org/10.14216/kjco.11008
Colorectal Oligometastases Treated by Stereotactic Body Radiotherapy
Mi Sook Kim
Korea Cancer Center Hospital
대장암의 소수전이에 대한 정위적 체부 방사선치료의 역할
김미숙
가톨릭대학교 의과대학 외과학교실
Corresponding Author: Mi Sook Kim ,Tel: +82-2-2626-1147, Fax: +82-2-2626-1148, Email: koreasurgery@gmail.com
Received: May 23, 2011;  Accepted: June 20, 2011.
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ABSTRACT
Purpose: This study evaluated the role of stereotactic body radiotherapy (SBRT) for oligometastases from colorectal cancer(CRC). Materials and results: Between 2003 and 2009, total of 41 patients with 50 lesions confined to one organ from colorectal cancer and treated with high dose SBRT above 45 Gy or more were involved in. The metastatic organs were the lymph node (18 patients), lung (12) and liver (11). SBRT doses ranged from 45 to 60 Gy in 3 fractions (median 48 Gy). The 3-year local control and overall survival rates were 64% and 60%, and the respective 5-year rates were 57% and 38%. Cumulative gross tumor volume and SBRT dose were statistically significant prognostic factors for local control. The grade 3 or 4 intestinal complications occurred in 3 patients(7%) to receive 48 or 51 Gy.
Conclusions:High dose SBRT °√ 45Gy for oligometastases from CRC showed comparable result with surgical series. For improvement of local control, higher dose °√ 48Gy is recommend when possible. However, considering severe complications above grade 3 occurred in °√ 48 Gy, further study will be required to define the optimal constraint for normal tissue such as intestine.
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