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Korean Journal of Clinical Oncology > Volume 10(2); 2014 > Article
Al-Amri: Surgical management of thyroid tumor: single institutional experience of Eastern province of Saudi Arabia

ABSTRACT

Purpose:

To review the pattern of thyroid tumor, demographic data of the patients, sensitivity, and specificity of fine needle aspiration cytology.

Methods:

This is a retrospective analysis of patients who underwent total or near-total thyroidectomy at King Fahad Hospital of the University between 1982 and 2008. Data were analyzed for demographic characteristics, type of thyroid tumors, fine needle aspirations cytology (FNAC) yields and surgical complications.

Results:

A total of 143 patients with thyroid tumors underwent throidectomy. Their median age was 37.5 years. Females were predominantly affected (81%) with female to male ratio of (4.29:1). Thyroid carcinoma accounted for (75%) while benign tumors for (25%). The most common thyroid epithelial cancer was papillary type (74%) and was limited to thyroid tissues in almost two third of cases. Non-epithelial cancer in the form of thyroid lymphoma accounted for (4.89%) of the cases. FNAC sensitivity was 56% and specificity 92%. Surgical complications occurred in 18% of the patients.

Conclusion:

The commonest malignant thyroid cancer was papillary carcinoma. Thyroid cancer was more common in females. FNAC is highly accurate to confirm thyroid cancer but less sensitive in this study. Surgical complications were relatively minimal.

INTRODUCTION

Clinically diagnosed thyroid cancer accounts for 6.1% of all newly diagnosed cases of cancer in Saudi Arabia and are ranked fourth in males and second in females with male to female ratio of 3.46:1 and the average age-specific incidence rate (AIR) in males is 1.6/ 100,000 and 5.1/100,000 in females with an overall AIR of 3.3/ 100,000 [1].
Thyroid cancer is the most common of all endocrine malignancies, accounting for 87% of all endocrine gland tumors. Thyroid carcinoma though relatively rare, is the second most common cancer among Saudi women [1-4].
Fine needle aspiration cytology (FNAC) is still the primary method for investigation of malignancy in patients with thyroid nodules and selecting patients for thyroid surgery [5,6].
Thyroid cancers have varied clinical presentations including solitary nodule or multi-nodular goiter. Other clinical manifestations include dysphagia, dyspnea or symptoms of thyrotoxicosis; however, typically they present as asymptomatic thyroid nodules in clinically euthyroid patients [7-9].
Standard therapy of thyroid cancer includes total thyroidectomy, radioactive iodine ablation and thyroxine replacement in sufficient dose to suppress thyroid-stimulating hormone (TSH) [8]. New therapies are being developed to target specific mutation pathways and intra-nuclear modulators of gene regulation.
The purpose of this study was to review the pattern of thyroid tumors in our area, their clinical presentation, demographic characteristics, sensitivity, and specificity of FNAC as well as surgical complications.

METHODS

A retrospective review was conducted of all patients that underwent thyroid surgery between 1982 and 2008 at King Fahd Hospital of the University in the Eastern Province of Saudi Arabia. The data were collected from the admission and out-patients records of these patients, with review of their treatment and investigation charts including surgical notes, radiological, laboratory and histo-pathological reports. Patients with thyroid cancer proven by cytology or histopathology who underwent total or near-total thyroidectomy were included in this study. The study had the approval of the ethics committee of University Of Dammam.
Follow up included, an assessment of local relapse in remaining thyroid gland, neck lymph nodes or distant metastasis.
Preoperative FNAC when available was compared with postoperative his-to-pathological diagnosis. There were 54 patients with FNAC reports prior to surgical interventions and postoperative his-to-pathological reports as shown in Table 1.

Histology

All cases were reviewed and interpreted according to the 2004 WHO classification of thyroid tumors by one pathologist [10].
Histology included available positive or negative FNAC for malignant cells and surgical excision of thyroid lesions which were classified as: Benign, no maligant cells seen; Malignant, positive for follicular, papillary, anaplastic and medullary carcinoma or lymphoma.

Statistical analysis

The numbers of true positive (TP), true negative (TN), false positive(FP), and false negative (FN) results were calculated. Suspicious/malignant FNABs were considered as TP in cases where postoperative reports revealed malignancy, and considered FP if no malignancy was found. The benign FNAB report was considered as a TN if postoperative reports were benign and FN if it was reported as malignant. From these, the following statistical values were calculated as shown in Table 1.
  • Percentage sensitivity: (TP/TP+FN)×100

  • Percentage specificity: [1-(FP/FP+TN)](TN/TN + FP)×100

  • Positive predictive value: (TP/TP+FP)×100

  • Negative predictive value: (TN/TN+FN)×100

RESULTS

Table 2 illustrates the demographic characteristic of patients with thyroid carcinoma. Sixty percent were Saudis and 40% non-Saudis. The median age was 38 years with a range of 14 to 85 years; 81%were females. All patients presented with a neck mass, 20% had dysphagia, 16% neck pain, 12% dyspnea, 11% hoarseness, 3% symptoms of thyrotoxicosis and only 2% presented with weight loss. In 75%, the diagnosis was confirmed as primary malignant carcinoma and 25% showed benign disease. Differentiated thyroid cancer (well or poorly) was seen in 100 patients with 74% having papillary carcinoma. Seventy-three percent presented with the disease limited to thyroid tissue as shown in Table 3. Seven patients had primary thyroid lymphoma, stage I.
The available data of FNAC and histopathology reports were evaluated for sensitivity and specificity as shown in Table 1. Specificity was high (92%) and negative predictive value was 89.2%. However, sensitivity was low (56%) and positive predictive value was 58.8%. Surgical complications occurred in 18% of patients including one death as shown in Table 4.

DISCUSSION

Thyroid cancer is the commonest malignant endocrine tumor but comprises only about 1% of all malignancies and typically presents as unilateral painless thyroid nodule in a clinically euthyroid patient. In Saudi Arabia, thyroid carcinoma was responsible for 6.1% of all newly diagnosed cancer in the year 2004 and ranked second among female population [1]. Female to male ratio was reported as 2.66:1 but in our study, the ratio was 4.29:1. In contrast, the western region of Saudi Arabia, there was slight male predominance with male to female ratio of 1.1:1 [11].
The median age of our patients was 37.8 years similar to Saudi registry of cancer [1]. Younger age at presentation was reported in Yemen and other studies in Saudi in whom two thirds of the patients were younger than 40 years [12-14].
Our study showed that all of the patients presented with thyroid gland nodules with infrequent local compressive symptoms such as dysphagia, dyspnea and hoarseness. These symptoms are not specific for malignant diseases and may present in benign conditions or absent in malignant conditions [14,15]. Benign lesions accounted for only 25%. Other non-malignant lesions such as, simple goiter, thyroididtis, granuloma, lipoma, and cyst were excluded from our analysis.
In this study, papillary carcinoma was more frequent than the other variant of thyroid carcinoma, and accounted for 74%. This histo-pathologic distribution of thyroid cancer is comparable to international literature, as well as with what has been reported previously from Saudi Arabia [1,3,11,13,15-18].
Papillary carcinoma has been reported as the commonest malignant thyroid tumor with a variable frequency of 57% to 93% [13,19-22]. It is interesting to note that papillary carcinoma of thyroid gland varied in many studies accounting for 60% in Pakistan, 63.6% in France, 87% in Spain, and 100% in India.
Medullary thyroid carcinoma accounts for approximately 4% of all thyroid cancers in the United States [23]. It was not observed in our study. This could be due to under diagnosis, small sample size of our study or probably genetic reasons.
Primary lymphoma of thyroid is rare. However, it should always, be considered in the differential diagnosis of patients with thyroid tumors since its therapy and prognosis differs from those of other thyroid malignancies. Primary thyroid lymphomas represents 1%–5% of all malignant thyroid tumors [24,[25]. In our study, primary thyroid lymphoma, primarily, diffuse large B-cell lymphoma accounted for 4.89% of malignant thyroid tumors.
Since its introduction in 1952, Soderstran had established the FNAC biopsy as a safe, simple, reliable, and invaluable method for preventing unnecessary surgery. Nowadays FNAC is the diagnostic investigation of choice in the majority of thyroid clinics and the single most accurate method for differentiating benign from malignant thyroid nodules [3,16,26,27].
In this study, FNAC showed sensitivity of 56%, specificity of 92%, positive predictive value of 58.8%, and negative predictive value of 89.2%. These results are comparable to data from other studies [28]. Patient’s history, physical examination, thyroid ultrasound guided FNAC studies, experienced thyroid surgeons, endocrinologists, and pathologists may help to increase the sensitivity and the diagnostic accuracy to avoid missing a diagnosis of carcinoma or subjecting patients to unnecessary surgery.
Complications of thyroid surgical procedures nowadays have been low with an acceptable morbidity and mortality. Studies indicate that death rate is zero to less than one percent [29,30].
The two national studies from Central region [11] and Western region [14] of Saudi Arabia have reported papillary carcinoma as the commonest type of thyroid cancer 89% and 82%, respectively, comparable to the 74% reported in our study. Morbidity in the Central region was 6.8% with zero mortality. In the Western region study, mortality was 2.2%. In our study, morbidity and mortality were 18% and 0.07% respectively.
The main treatment of thyroid malignant diseases includes total or near-total thyroidectomy, which is the treatment of choice for all types of thyroid cancer except primary thyroid lymphoma. L-thyroxine is essential to suppress TSH especially for papillary and follicular tumors. Radioactive iodine may improve survival in patients with well-differentiated papillary and follicular tumors with certain indications. Our patients were treated with total or near-total thyroidectomy, L-thyroxine suppression or referral to other hospitals.
The permanent complications of surgical intervention are mainly recurrent laryngeal nerve palsy and hypoparathyroidism. Follow up of our patients were not consistent, since some patients were referred to other hospitals and others disappeared from follow up. However, for those who had follow-up and had no other treatment other than surgical resection and L-thyroxine suppression, 8.8% had recurrences of thyroid cancer either local or distant. These recurrences occurred within 3 years of follow-up. Two patients with primary thyroid lymphoma were treated with chemotherapy and had no recurrence.
The limitations of our study include the small sample size, its retrospective nature over long period, enrolled patients were managed by different teams, cases were from a single hospital and not all patients had follow up. The findings might therefore, not be reflective of the overall general population.
In conclusion, our study showed that patients in the eastern province of Saudi Arabia with thyroid cancer were seen predominantly in females in a relatively younger population with a median age of 37.8 years. All the patients presented with thyroid nodules, 74% of which were papillary carcinoma and 73% were limited to the thyroid tissues. Primary lymphoma of thyroid gland accounted for 4.9%. The specificity was 92% and the sensitivity 56%. The main surgical complications were not different from other studies.

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

ACKNOWLEDGMENTS

I would like to extend my sincere gratitude to Professor Abdulaziz Al-Quorain for his valuable contribution and revising the manuscript.

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Table 1.
Association between FNAC and histopathology
Histopathology/FNAC Carcinoma Benign Total
Malignant TP=10 FP=3 17
Benign FN=8 TN=33 37
Total 18 36 54

Sensitivity=TP/TP+FN=10/10+8=56%. Specificity=TN/TN+FP=33/33+3=92%. Positive predictive value=10/17=58.8. Negative predictive value=33/37=89.2.

FNAC, fine needle aspirations cytology; TP, true-positive; FP, false-positive; FN, falsenegative; TN, true negative.

Table 2.
Demographic characteristics of patients with thyroid carcinoma
Characteristics No. (%)
Nationality
 Saudi 86 (60)
 Non-Saudi 57 (40)
Age (yr)
 Range 14-85
 Median 37.8
Sex
 Female 116 (81)
 Male 27 (19)
Presenting symptoms
 Neck mass 143 (100)
 Dysphagia 22 (20)
 Pain 17 (16)
 Dyspnea 13 (12)
 Hoarseness 12 (11)
 Thyrotoxicosis 3 (3)
 Weight loss 2 (2)
Type of thyroid tumors
 Benign 36 (25.17)
 Carcinoma 100 (69.93)
 Lymphoma 7 (4.89)
Table 3.
Histological type and staging of thyroid tumors
Primary thyroid cancer No. (%)a)
Type of carcinoma 100 (100)
Papillary 74 (74)
Follicular 14 (14)
Hurthle cells 7 (7)
Anaplastic 5 (5)
Stage
 Limited to thyroid tissues 77 (73)
 Lymph node involvement 21 (20)
 Distant metastasis 8 (7)
 Type of lymphomab) 7 (100)
  Diffuse large B-cell lymphoma (%) 71.43
  Follicular lymphoma (%) 28.57

a) Benign lesion excluded;

b) Primary lymphoma of thyroid stage I.

Table 4.
Complications of surgery
Complications No. (%)
Death 1 (0.07)
Recurrent laryngeal nerve palsy 10 (7.35)
Hypothyroidism 2 (1.47)
Hypoparathyroidism 1 (0.07)
Recurrence of thyroid cancera) 12 (8.8)
 Local 8 (5.9)
 Distant 4 (2.9)

a) Follow-up 3 years.

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