Systemic overview of 5-FU based locoregional chemotherapy -focused on colorectal cancer-

Kim, Hee Cheol

REVIEW

Korean J Clin Oncol. 2005;1(1): 92-99.

Systemic overview of 5-FU based locoregional chemotherapy -focused on colorectal cancer-

Hee Cheol Kim

Department of surgery, University of Ulsan college of medicine, Asan Medical Center, Colorectal clinic

5-FU를 이용한 국소 항암요법의 전반적 이해 - 대장암을 중심으로

김희철

울산의대 의과학교실 및 서울아산병원, 대장항문클리닉

Corresponding Author: Hee Cheol Kim ,Tel: 82-2-3010-3937, Fax: 82-2-474-9027, Email: hakim@amc.seoul.kr

Received: May 10, 2005; Accepted: June 20, 2005.

ABSTRACT

There are a variety of treatment options for patients with metastatic colorectal cancer confined to the liver. Although surgical resection is the only curative modality, a majority will not be able to undergo surgery. Alternative methods for treating this population have focused on the feasibility of hepatic arterial infusion of chemotherapy. Randomized trials evaluating the treatment of unresectable disease with hepatic artery infusion therapy have demonstrated higher response rates than those seen with systemic chemotherapy but variable results of survival benefit. With newly developed chemotherapeutic agents and technical advancement, several randomized trials of hepatic arterial infusion chemotherapy for hepatic metastasis of colorectal cancer are in the middle of ongoing. In this review, we will discuss about hepatic artery infusion chemotherapy regarding selection of patient, ideal chemotherapeutic agents, technique for catheter insertion and clinical outcomes of randomized trials.

Keywords: colorectal neoplasm | metastasis | perfusion | regional | liver