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Korean Journal of Clinical Oncology > Volume 8(2); 2012 > Article
ORIGINAL ARTICLE
Korean J Clin Oncol. 2012;8(2): 44-49.         doi: https://doi.org/10.14216/kjco.12016
Diagnostic Value of Positron Emission Tomography-Computed Tomography (PET/CT) in Detection of Recurrence after Curative resection for Colorectal Cancer
Young Ki Hong, Woo ram Kim1, Yoon Jung Choi2, Jung Gu Kang
1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
2Department of Surgery and Pathology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea
Corresponding Author: Jung Gu Kang ,Tel: 031-900-0216, Fax: 031-900-0343, Email: kangski@nhimc.or.kr
Received: November 5, 2012;  Accepted: December 7, 2012.
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ABSTRACT
Introduction: Accurate detection of recurrent colorectal cancer remains a diagnostic challenge. The purposes of this study were to evaluate the diagnostic value of Positron Emission Tomography-Computed Tomography (PET/CT) using fluor-18-deoxyglucose (FDG) in Detection of Recurrence after Curative resection for Colorectal Cancer.
Materials and methods: We performed a retrospective review of 248 patients who underwent PET/CT for surveillance of colorectal cancer after curative resection between June 2008 and April 2011. Recurrence of colorectal cancer was validated by histopathologic examination or serial imaging study follow-up.
Results: Of the 248 patients (149 males) included in the study, thirty-six patients (14.5%) were confirmed as recurrence. Liver was the most common site of recurrence (n=13). A total 472 PET/CT were conducted in 248 patients during follow-up period. The sensitivity and specificity of PET/CT were 0.921(95% CI 0.908-0.934) and 0.981(95% CI 0.975-0.987) for detecting tumor recurrence. The sensitivity and specificity of contrast enhanced computed tomography (CECT) were 0.902(95% CI 0.888-0.916) and 0.952(95% CI 0.942-0.952). CEA elevation was shown in only 13 cases (36.1%) of patients with recurrence. The treatment plans of 26 cases (10.5%) were altered by PET/CT findings. The curative surgical tumor resection procedure was performed in 15 out of 36 patients. In 3 cases which CECT showed negative findings, PET/CT had detected unexpected metachronous cancer (one colon, two bladders).
Conclusions: Additional PET/CT on CECT seems to provide high detection rate of tumor recurrence after curative resection for colorectal cancer and other critical information such as unexpected secondary malignancy.
Keywords: Colorectal cancer | Recurrence | PET/CT
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